In view of high permeability and serious water channeling in Bohai oilfield, a new type selfassembled particles profile control system was investigated. Laboratory plugging and oil displacement experiments were carried out with different injection modes. Static experiments showed that self-assembled particles had good properties of heat-resistance and salt-resistance, and it was applicable on the reservoir conditions of 65 ℃ and 35 000 mg/L. Plugging experiments showed that for sand-filled pipe which permeability was about 10 000×10 ^-3 μm ² , after particles plugging with guanidine gum or polymer as suspension liquid, the permeability was dropped to about 3 000×10 ^-3 μm ² and effective plugging rate was above 70%. Oil displacement experiments showed that for parallel sand-filled pipes which permeability was about 20 000×10 ^-3 ，4 000×10 ^-3 μm ² , when water-flooding recovery was 27.34%～28.17%, the degree of extraction can be improved by 28.57%～38.76% after injecting 0.4 PV self-assembled particles displacement system, and it can be up to 55.91%～66.80% finally. It should be noted the injection mode with guanidine gum or polymer was better. Mechanism analysis revealed selfassembled particles displacement system had plugging functions such as filling, bridging and adhesion.